A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an on or off switch in many cellular functions.
Nonreceptor tyrosine kinases (nRTKs) are cytoplasmic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate.
R. Roskoski Jr. Pharmacological Research 68 (2013) 6894 69 3. 3. Structure of quiescent ALK protein kinase.
Crizotinib (PF ) is an ALK and cMet kinase inhibitor. It inhibited cell proliferation in ALKpositive ALCL cells (IC50s30 nM). Find all the information.
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a.